自拟止咳贴中药穴位贴敷对于小儿肺炎的疗效观察

黄菁娟, 敖小冬, 胡亮, 丁小红

上海医药 ›› 2024, Vol. 45 ›› Issue (4) : 26-28.

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主管单位:上海市经济和信息化委员会
主办单位:上海医药行业协会
中国标准连续出版物号:
ISSN 1006-1533
CN 31-1663/R
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上海医药 ›› 2024, Vol. 45 ›› Issue (4) : 26-28.
全科医疗和社区护理

自拟止咳贴中药穴位贴敷对于小儿肺炎的疗效观察

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Effect observation of self-designed cough relieving plaster for traditional Chinese medicine acupoint application on pediatric pneumonia

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文章历史 +

摘要

目的:探讨自拟止咳贴中药穴位贴敷对小儿肺炎的治疗效果。方法:纳入2020年1月—2022年11月江西省新余市妇幼保健院收治的小儿支气管肺炎患儿72例,采取随机数字表法分成两组各36例。对照组接受抗感染、止咳、化痰、退热、雾化吸入等常规西医治疗,观察组在此基础上接受自拟止咳贴中药穴位贴敷治疗,1次/d,2~4 h/次,5~7 d为1疗程。两组均治疗1个疗程。比较两组患儿的治疗效果、症状改善时间、治疗前后中医证候积分变化情况以及不良反应(局部皮肤充血发红、瘙痒、皮疹等)发生情况。结果:观察组治疗总有效率为100.00%,高于对照组的88.89%(P<0.05)。观察组发热消失时间、咳嗽消失时间、气喘消失时间、肺部啰音消失时间均短于对照组(P<0.05)。观察组治疗后中医证候积分低于对照组(P<0.05)。两组治疗后发热积分、咳嗽积分、喘促积分、面赤口渴积分、烦闷急躁积分、喉间痰鸣积分、气急鼻煽积分均低于同组治疗前(P<0.05),且观察组低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:自拟止咳贴中药穴位贴敷能够提升小儿支气管肺炎的治疗效果,促进患儿康复,值得临床推荐。

Abstract

Objective: To explore the effect of self-designed cough relieving patch for traditional Chinese medicine acupoint application on children’s pneumonia. Methods: A total of 72 children with bronchopneumonia admitted to Xinyu Maternal and Child Health Care Hospital from January 2020 to November 2022 were included, and divided into two groups with 36 cases with random number table method. The control group was treated with conventional western medicine such as anti-infection, cough relieving, expectorant, antipyretic, nebulized inhalation, etc. And on these bases the observation group was treated with self-designed cough relieving plaster for traditional Chinese medicine acupoint application treatment once a day, 2-4 hours per time, 5-7 days as a course of treatment. Both groups were treated for one course. The treatment effect, symptom improvement time, change of TCM syndrome score before and after treatment, and occurrence of adverse reactions(local skin congestion, redness, itching, rash, etc.) were compared between the two groups. Results: The total effective rate of treatment was 100.00% in the observation group, which was higher than that 88.89% in the control group(P<0.05). The disappearance times of fever, cough, asthma and lung rale in the observation group were shorter than those in the control group(P<0.05). After treatment, the TCM syndrome score in the observation group was lower than that in the control group(P<0.05). After treatment, the integrals of fever, cough, dyspnea, face redness and thirst, boredom and impatience, interlaryngeal phlegm and stridor, and dyspnea and nasal fan in the two groups were lower than those in the same groups before treatment(P<0.05) and the treatment group was lower than the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: The self-designed cough relieving plaster for traditional Chinese medicine acupoint application can improve the therapeutic effect of children with bronchopneumonia and promote the rehabilitation of children, which is worthy of clinical recommendation.

关键词

小儿肺炎 / 穴位贴敷 / 治疗效果 / 中医证候积分 / 不良反应

Key words

pediatric pneumonia / acupoint application / treatment effect / traditional Chinese medicine syndrome score / adverse reaction

引用本文

导出引用
黄菁娟, 敖小冬, 胡亮, 丁小红. 自拟止咳贴中药穴位贴敷对于小儿肺炎的疗效观察[J]. 上海医药, 2024, 45(4): 26-28
HUANG Jingjuan, AO Xiaodong, HU Liang, DING Xiaohong. Effect observation of self-designed cough relieving plaster for traditional Chinese medicine acupoint application on pediatric pneumonia[J]. Shanghai Medical & Pharmaceutical Journal, 2024, 45(4): 26-28
中图分类号: R256.110.5   
小儿肺炎是儿科常见的呼吸系统感染性疾病,以支气管肺炎为主,临床表现为发热、咳嗽、气喘等典型症状。临床治疗主要采用止咳平喘、抗炎、抗病毒等综合对症治疗,但部分患儿恢复较慢[1]。中西医结合治疗小儿支气管肺炎具有辨证治疗、标本兼治、不良反应少等临床优势,能弥补常规西药的不足,近几年逐渐受到临床医师的关注[2-3]。穴位贴敷是中医外治法的一种,集中药理与经络穴位理论于一体,能够产生温通经络、调节脏腑功能、调和气血的作用[4]。本院在此方面积累了较多经验,针对小儿支气管肺炎痰热壅肺证的病因病机选择自拟止咳贴中药穴位贴敷配合西药进行治疗,现将临床效果进行分析,以期为该病的中西医治疗提供参考。

1 资料与方法

1.1 一般资料

纳入2020年1月—2022年11月江西省新余市妇幼保健院收治的小儿支气管肺炎患儿72例,均符合《儿科学(第九版)》[5]中小儿支气管肺炎诊断标准,以及《中医儿科学》[6]“肺炎喘嗽”痰热壅肺证中医诊断标准,并经肺部影像学检查、听诊及实验室生化检测等确诊。采取随机数字表法将患儿分成两组各36例。观察组男女比例为20:16,年龄为4个月~6岁,平均(1.51±1.02)岁,病程为1~5 d,平均(3.11±0.94)d;对照组男女比例为19:17,年龄为4个月~6岁,平均(1.59±1.05)岁,病程为1~5 d,平均(3.09±0.98)d。两组上述基本资料间差异无统计学意义(P>0.05)。家属对本研究内容了解并签署知情同意书。排除合并严重循环系统或免疫系统疾病者、合并先天性疾病或传染性疾病者、有穴位贴敷禁忌证或对本研究所用药物过敏者及合并其他重要脏器功能障碍者。

1.2 方法

对照组接受常规西医治疗,包括抗感染、止咳、化痰、退热、雾化吸入等对症治疗。雾化吸入药物选择吸入用布地奈德混悬液和硫酸特布他林雾化吸引用溶液等,布地奈德每次1 mg;特布他林按患儿体重≥20 kg给予5 mg/次,体重小于20 kg则2.5 mg/次,2~3次/d,5~7 d为1疗程。治疗1个疗程。
观察组在此基础上接受自拟止咳贴中药穴位贴敷治疗。①热咳贴制作。将杏仁60 g、桃仁60 g、栀子60 g、黄芩60 g、浙贝母60 g、蒲公英60 g、前胡60 g和枇杷叶60 g研成细末,用姜汁和醋调制成糊状,制作成20 mm×20 mm×5 mm的药饼备用。②穴位贴敷。将热咳贴贴敷于患儿双侧肺俞穴、膻中穴,1次/d,2~4 h/次,期间密切观察患儿皮肤变化和耐受情况。5~7 d为1疗程。治疗1个疗程。

1.3 观察指标

比较两组患儿的治疗效果、症状改善时间、治疗前后中医证候积分变化情况以及不良反应(局部皮肤充血发红、瘙痒、皮疹等)发生情况。中医证候积分评估参考《中医病证诊断疗效标准》[7],发热、咳嗽、喘促等主症按照无(0分)、轻度(2分)、中度(4分)、重度(6分)计分,面赤口渴、烦闷急躁、喉间痰鸣、气急鼻煽等次症按照无(0分)、轻度(1分)、中度(2分)、重度(3分)计分。
治疗效果评价[8]:患儿发热、咳嗽、气喘等症状消失,影像学结果恢复正常为治愈;症状明显改善,影像学结果显示病灶明显吸收为好转;未达到以上标准为无效。总有效率=(治愈例数+好转例数)÷总例数×100%。

1.4 统计学分析

采用软件SPSS 22.0进行数据分析,计量数据表示为均数±标准差,行t检验;计数数据表示为百分比,行χ2检验。P<0.05为差异有统计学意义。

2 结果

2.1 两组治疗效果比较

观察组治疗总有效率为100.00%(36/36),高于对照组的88.89%(32/36,P<0.05),见表1
表1 两组治疗效果比较 [n(%)]
分组 治愈 好转 无效 总有效
观察组(n=36) 26(72.22) 10(27.78) 0(0.00) 36(100.00)
对照组(n=36) 21(58.33) 11(30.56) 4(11.11) 32(88.89)
χ2 4.235
P值 <0.05

2.2 两组症状改善时间比较

观察组发热消失时间、咳嗽消失时间、气喘消失时间、肺部啰音消失时间均短于对照组(P<0.05),见表2
表2 两组症状改善时间的比较 (x¯±s,d)
分组 发热消失时间 咳嗽消失时间 气喘消失时间 肺部啰音消失时间
观察组
(n=36)
2.31±0.64 4.85±0.98 4.64±1.13 4.04±1.02
对照组
(n=36)
2.97±0.77 6.12±1.40 5.82±1.38 5.58±1.24
t值 6.188 7.776 6.265 9.059
P值 <0.05 <0.05 <0.05 <0.05

2.3 两组治疗前后中医证候积分比较

两组治疗后发热积分、咳嗽积分、喘促积分、面赤口渴积分、烦闷急躁积分、喉间痰鸣积分、气急鼻煽积分均低于同组治疗前(P<0.05),且观察组低于对照组(P<0.05),见表3
表3 两组治疗前后中医证候积分比较 (x¯±s,分)
分组 发热 咳嗽 喘促 面赤口渴 烦闷急躁 喉间痰鸣 气急鼻煽
观察组(n=36)
治疗前 4.97±0.72 4.88±0.65 4.54±0.66 2.18±0.43 2.31±0.45 2.34±0.37 2.29±0.32
治疗后 1.21±0.31 1.04±0.27 0.97±0.26 0.78±0.15 0.81±0.20 0.77±0.17 0.79±0.14
t值 31.333 35.446 32.455 19.535 20.000 25.459 28.125
P值 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01
对照组(n=36)
治疗前 4.96±0.68 4.49±0.70 4.51±0.71 2.12±0.37 2.29±0.42 2.28±0.38 2.30±0.34
治疗后 2.02±0.37 1.95±0.32 1.97±0.28 1.27±0.33 1.31±0.28 1.16±0.22 1.07±0.23
t值 25.941 21.771 21.465 13.784 14.000 17.684 21.706
P值 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01
t值组间 15.677 20.222 23.077 19.600 15.000 13.765 12.000
P值组间 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01 <0.01

2.4 两组不良反应情况比较

观察组发生局部皮肤充血发红、瘙痒、皮疹不良反应各1例,对照组无不良反应发生,两组间比较差异无统计学意义(χ2=3.130,P>0.05)。

3 讨论

小儿支气管肺炎临床发病率较高,目前尚无特效治疗药物,一般选择抗炎、抗菌、平喘等对症治疗以改善患儿炎症状态和肺循环,但部分患儿获益欠佳[9]。中医学认为小儿支气管肺炎属“肺炎喘嗽”范畴,主要因小儿正气不足、肺脾气弱,外感风温之邪而致肺失宣降、肺气郁闭,上源不利,水湿内停,变生痰热,病久不愈,临床辨治应以清热解毒、降气平喘、宣肺化痰为主要原则[10]。穴位贴敷是一种操作简单的中医外治方法,通过皮肤吸收药物成分,并对穴位进行刺激而达到调节经络脏腑的作用[11]
本研究即在常规西药基础上采取中药穴位贴敷进行治疗,所用热咳贴为自拟方,方中杏仁可止咳平喘、降气,桃仁能破血行瘀,栀子可清热利湿、泻火除烦,黄芩能清热燥湿、泻火解毒,浙贝母可清热化痰、散结解毒,蒲公英能清热解毒、利尿散结,前胡可宣散风热、下气消痰,枇杷叶能清肺止咳,诸药配伍共奏止咳平喘、清泻肺热、燥湿化痰之功效[12]。现代药理学研究也表明,杏仁有明确的抗炎、镇痛作用,还可促进肺表面活性物质的合成;桃仁、栀子、黄芩、蒲公英、前胡均有不同程度的抑菌抗炎效果;枇杷叶也可抗炎、止咳;浙贝母还有一定的扩张支气管平滑肌作用[13]。肺俞、膻中穴于胸部正中,是气管、支气管与肺集中的体表位置,穴位贴敷刺激膻中穴可宽心顺气、祛痰利窍,再配合肺俞穴以宣通肺气,两者相合可产生肃肺化痰止咳的效果。热咳贴配合穴位可使中药经皮肤进入穴位,并沿经络到达患儿体内,产生清热化痰、止咳平喘等作用[14]。现代医学研究也表明,穴位贴敷有一定的生物学刺激作用,能够借助皮肤血管及神经感受器进行有效传导,进而激发机体免疫系统,有效抑制炎症[15]。本研究结果显示,观察组治疗总有效率高于对照组(P<0.05),小儿肺炎症状消失时间短于对照组(P<0.05),中医证候积分低于对照组(P<0.05),证实自拟止咳贴中药穴位贴敷对小儿支气管肺炎有良好的辨治效果,可与抗炎抗病毒药物协同作用,促进炎症吸收,缓解患儿临床症状,有效控制病情,缩短康复时间,提升患儿的治疗预后,与先前报道一致[16]。在整个治疗期间,仅有少部分患儿在穴位贴敷后出现轻度局部皮肤充血发红、瘙痒或皮疹等不良反应,不经特殊处理可自行消失,也表明自拟止咳贴中药穴位贴敷的不良反应很少,安全性令人满意。
综上所述,自拟止咳贴中药穴位贴敷能够提升小儿支气管肺炎的治疗效果,促进患儿康复,值得临床推荐。

参考文献

[1]
Zhang J, Wang T, Li R, et al. Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia[J]. BMC Infect Dis, 2021, 21(1): 67.
Recently, many cases of pneumonia in children with Mycoplasma pneumoniae infection have been shown to have varying degrees of intrabronchial mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of patients with Mycoplasma infection are analyzed in this study. The risk factors for M. pneumoniae pneumonia (MPP) mucus plug formation in children are explored, and a risk factor scoring system is established.MPP patients treated with bronchoscopy were retrospectively enrolled in the study from February 2015 to December 2019. The children were divided into a mucus plug group and a control group according to the presence or absence of mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of the two groups of children were compared. Univariate and multivariate logistic regression models were used to identify the risk factors for MPP mucus plug formation. The receiver operating characteristic (ROC) curve was drawn to evaluate the regression model and establish the MPP mucous plug risk factor scoring system.A univariate analysis showed that the children in the mucous group were older and had a longer fever duration, longer hospital stay, higher fever peak, more cases of wheezing symptoms and allergies, and azithromycin or corticosteroids were administered later. In addition, neutrophil, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), sputum MP-DNA copy number, and total immunoglobulin A (IgA) levels were higher, while prealbumin (PA) levels were lower. The ROC curve analysis showed that children with MPP had PA ≤144.5 mg/L, had used corticosteroids during the course of the illness of ≥4.5 days, CRP ≥12.27 mg/L, an LDH ≥ 462.65 U/L, and there was a possibility of intra-airway mucus formation. The independent risk factors were scored according to their odds ratio (OR) value. Among the 255 children with MPP, the high-risk group had 44 (83.02%) mucus plugs out of 53; the middle-risk group had 35 (34.3%) mucus plugs out of 102; and the low-risk group had 11 (11%) mucus plugs out of 100.PA levels, timing of corticosteroid use (use in the first few days), CRP levels, and LDH levels were independent risk factors for MPP mucus plug formation. This provides a basis for the early identification of MPP in children combined with mucus plug formation.
[2]
李冬梅, 宋永福, 王永吉. 中医药治疗小儿肺炎的临床现状[J]. 医学食疗与健康, 2022, 20(6): 28-31.
[3]
刘宾. 基于数据挖掘的小儿肺炎中医辨证分型研究[J]. 江西中医药大学学报, 2022, 34(2): 53-55.
[4]
舒慧琳, 刘志瑜, 段丽, 等. 中药穴位贴敷联合西医治疗小儿支气管肺炎的研究[J]. 医学食疗与健康, 2021, 19(3): 39-40.
[5]
王卫平, 孙锟, 常立文. 儿科学[M]. 9版. 北京: 人民卫生出版社, 2018: 45-46.
[6]
汪受传, 俞景茂, 马融, 等. 中医儿科学[M]. 北京: 中国中医药出版社, 2007: 75.
[7]
国家中医药管理局. 中医病证诊断疗效标准[M]. 北京: 中国中医药出版社, 2017: 57.
[8]
Begom A, Choudhury AM, Islam MN, et al. Clinical and radiological evaluation of children aged 2 months to 5 years with severe pneumonia according to WHO guideline[J]. Mymensingh Med J, 2018, 27(4): 702-709.
Pneumonia is the leading cause of morbidity and mortality in children less than 5 years of age in developing countries like Bangladesh. Although WHO guideline classified severe pneumonia by symptoms and signs of the patients, radiological and laboratory investigations were not studied well. There was increasing number of cases of bronchiolitis which meet the criteria of WHO classified severe pneumonia are reported. The objective of the study was to assess the clinical and radiological parameters of severe pneumonia in 2 months to 59 months hospitalized children according to WHO guideline. This cross sectional study was conducted in pediatrics department of Mymensingh Medical College Hospital, Mymensingh, Bangladesh from July, 2015 to December 2015. Total 150 patients were included in this cross sectional study according to their clinical symptoms. Firstly, the chest x-ray was done in all the patients and radiographs were reviewed by an expert radiologist who was blind about the cases. Then the patients were classified as pneumonia and bronchiolitis according to the clinical features and radiology findings. Majority of the patients 83(55.3%) were between 2-6 months of age and mean age was 7.52±8.87. Maximum 105(70%) patients were male and 45(30%) were female. Most of them 70(47%) came from low middle class family. Regarding clinical features, all patients 150 had cough and chest indrawing. Ronchi found in 135(90%) patients, difficult breathing and fast breathing found in 130(87%) patients, crepitation in 122(81%) patients, wheeze in 93(62%) patients, dull on percussion in 36(21%) patients, bronchial breath sound in 25(17%) patients. Regarding radiological features, lobar consolidation was found in 18(12%) patients, patchy opacities in 42(28%) patients, which were radiological findings of pneumonia, while hyperinflation of lung present in 90(60%) patients, increased translucency in 82(54.6%), increased interstitial marking in 88(58.6%) patients, which were radiological findings of bronchiolitis. A total of 60(40%) admitted cases were diagnosed as pneumonia and 90(60%) cases diagnosed as bronchiolitis radiologically, which were predominant in WHO classified severe pneumonia (p<0.05). Wheeze was present in case of hyperinflation of lung in 78(83.8%), increased translucency in 67(72%) and increased interstitial marking in 70(75.2%) patients among radiological bronchiolitis (n=90). From above results we can concluded that Bronchiolitis was predominant among WHO guideline classified severe pneumonia.
[9]
卢建忠, 陈靖, 王春海. 小儿支气管肺炎的诊治进展探讨[J]. 名医, 2019, (1): 18; 155.
[10]
黄梦雪, 杜琳麟. 小儿肺炎中医外治法治疗进展[J]. 中国中西医结合儿科学, 2021, 13(6): 473-476.
[11]
刘爱娟, 李月灵. 中医内外治联合治疗小儿支气管肺炎的效果以及对患者血清炎症因子的影响[J]. 江西中医药大学学报, 2021, 33(3): 64-66.
[12]
卢琪, 冯爱民. 穴位贴敷促进0-3月婴儿肺炎湿啰音吸收32例[J]. 陕西中医药大学学报, 2019, 42(2): 85-87.
[13]
王继培, 丁晓华, 白彩颖, 等. 穴位贴敷联合小儿推拿辅助治疗婴幼儿支气管肺炎的疗效观察[J]. 甘肃科技纵横, 2020, 49(2): 53-55; 64.
[14]
Wang L, Pang L, Bai X, et al. Clinical efficacy on pediatric recurrent pneumonia treated with point application in summer for the prevention in winter[J]. Zhongguo Zhen Jiu, 2016, 36(3): 261-265.
[15]
王翠红. 中药穴位贴敷联合雾化吸入治疗小儿支气管肺炎35例临床观察[J]. 湖南中医杂志, 2021, 37(2): 64-65; 85.
[16]
汪蕾. 中药穴位贴敷联合布地奈德雾化吸入治疗小儿支气管肺炎的临床效果分析[J]. 名医, 2022, (5): 162-164.
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