
基于临床药学实践的药品综合评价和转化研究
Comprehensive evaluation and translational research of drugs based on clinical pharmacy practice
随着国家“转变药学服务模式,促进临床合理用药”政策的不断推进,临床药师除须掌握临床药物治疗相关知识之外,还要具备一定的科研能力,这对临床药师的个人职业发展至关重要,同时亦能助力医院药学学科建设。基于我院特色驻科闭环式药学服务模式,我院临床药学科在构建临床药师工作规范的同时还形成了医院药品临床综合评价环路,为医院药品筛选和转化研究提供支撑并取得了一定成果,提升了整个药师团队的科研水平。
With the continuous improvement of the national policy on “transforming the mode of pharmaceutical care to promote rational clinical drug use”, clinical pharmacists should not only master the relevant knowledge of clinical drug treatment, but also have scientific research skills, which are crucial for the personal professional development of clinical pharmacists and can also help the construction of hospital pharmacy. Based on the characteristic closed-loop pharmaceutical care model resident in clinical department, the Clinical Pharmacy Department of our hospital has formed a clinical comprehensive evaluation loop of hospital drugs while constructing the work standards of clinical pharmacists. This has provided support for hospital drug screening and translational research and has achieved some results, which finally improved the scientific research level of the whole pharmacist team.
驻科药学服务 / 药品临床综合评价 / 转化研究 / 合理用药 {{custom_keyword}} /
pharmaceutical care resident in clinical department / clinical comprehensive evaluation of drugs / translational research / rational drug use {{custom_keyword}} /
[1] |
国家卫生计生委办公厅, 国家中医药管理局办公室. 关于加强药事管理转变药学服务模式的通知[EB/OL]. (2017-07-12) [2023-11-03]. http://www.nhc.gov.cn/yzygj/s7659/201707/b44339ebef924f038003e1b7dca492f2.shtml.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[2] |
卫生健康委, 教育部, 财政部, 等. 关于加强医疗机构药事管理促进合理用药的意见[EB/OL]. (2020-02-26) [2023-11-03]. https://www.gov.cn/gongbao/content/2020/content_5522549.htm?ivk_sa=1024320u.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[3] |
孔令君, 相妍笑, 张硕. 基于CiteSpace国内妇产科药师科学研究现状可视化分析[J]. 中国药学杂志, 2021, 56(21): 1780-1784.
目的 分析我国妇产科药师进行药学科学研究的热点和趋势,针对妇产科药学研究发展情况进行可视化分析。方法 以CNKI数据库为检索对象,纳入2010~2020年妇产科药师发表的相关文献,使用可视化分析软件CiteSpace对所选文献进行分析,形成可视化科学网络图谱。结果 本研究共纳入文献3 424篇。结果显示,近十几年来妇产科药师文章发表数量显著增加,高频关键词共有10个聚类且与临床药学发展趋势相一致,25个高频关键词突现代表了妇产科药学领域的研究前沿,并直观显示出在本研究领域发表文章数量前10位作者。结论 截至目前,妇产科药师科学研究领域仍多集中于传统的合理用药、处方分析以及药学服务等方面,实验研究性质文章还是相对较少,妇产科药学研究仍有较大的发展空间。
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[4] |
万素馨, 方伟, 黄道秋, 等. 重庆市39家医疗机构临床药学服务发展现状的调查研究[J]. 中国药房, 2020, 31(1): 12-17.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[5] |
国家卫生健康委. 国家卫生健康委关于开展药品使用监测和临床综合评价工作的通知[EB/OL]. (2019-04-09) [2023-11-03]. http://www.nhc.gov.cn/yaozs/pqt/201904/31149bb1845e4c019a04f30c0d69c2c9.shtml.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[6] |
国家卫生健康委办公厅. 国家卫生健康委办公厅关于规范开展药品临床综合评价工作的通知[EB/OL]. (2021-07-28) [2023-11-03]. http://www.nhc.gov.cn/yaozs/s2908/202107/532e20800a47415d84adf3797b0f4869.shtml.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[7] |
刘抚瑶, 陈斌斌, 左宝建, 等. 我国药品临床综合评价的研究进展[J]. 中国药物经济学, 2023, 18(5): 23-28.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[8] |
国家药物和卫生技术综合评估中心国家卫生健康委卫生发展研究中心, 国家癌症中心, 国家卫生健康委药具管理中心. 抗肿瘤药品临床综合评价技术指南(2022年版试行)[EB/OL]. (2022-06-29) [2023-11-03]. http://www.nhei.cn/nhei/znfb/202206/c01d87a290664b01bf42a9dad769d69f/files/4e062c199b17474ca680da5aac3b6d89.pdf.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[9] |
国家药物和卫生技术综合评估中心国家卫生健康委卫生发展研究中心, 国家心血管病中心, 首都医科大学附属北京安贞医院, 等. 心血管病药品临床综合评价技术指南(2022年版试行)[EB/OL]. (2022-06-29) [2023-11-03]. http://www.nhei.cn/nhei/znfb/202206/c01d87a290664b01bf42a9dad769d69f/files/d4c3a96d751f44d4a78a8979ccf97cf6.pdf.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[10] |
国家药物和卫生技术综合评估中心国家卫生健康委卫生发展研究中心, 国家儿童医学中心, 国家卫生健康委药具管理中心. 儿童药品临床综合评价技术指南(2022年版试行)[EB/OL]. (2022-06-29) [2023-11-03]. http://www.nhei.cn/nhei/znfb/202206/c01d87a290664b01bf42a9dad769d69f/files/60c39855fa6048e6aae17323b1fbd546.pdf.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[11] |
季聪华, 刘姗, 张颖, 等. 基于诊疗大数据研究的循证医学证据等级思考[J]. 中华中医药杂志, 2019, 34(12): 5540-5542.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[12] |
Patients with type 2 diabetes have a high risk of non-alcoholic fatty liver disease (NAFLD) and related liver fibrosis. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated efficacy in improving NAFLD, while their effectiveness on liver fibrosis is limited in type 2 diabetic patients.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[13] |
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[14] |
中国临床肿瘤学会肿瘤与血栓专家共识委员会. 中国肿瘤相关静脉血栓栓塞症预防与治疗专家指南(2015版)[J]. 中国实用内科杂志, 2015, 35(11): 907-920.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[15] |
李致玲, 李桂香. 消化道肿瘤与凝血功能的研究进展[J]. 中国卫生产业, 2014, 11(22): 197-198.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[16] |
陶婕妤, 程学芳, 李琴, 等. 某三甲医院住院消化道肿瘤患者抗凝预防现状调查与分析[J]. 中国医药导报, 2021, 18(35): 63-67.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[17] |
叶念, 李琴, 熊学惠. 我院抗血小板药物致不良反应的帕累托图分析[J]. 中南药学, 2020, 18(12): 2088-2092.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[18] |
熊学惠, 刘芳, 潘凌, 等. 基于FAERS数据库的地舒单抗肌肉骨骼毒性数据挖掘[J]. 中国新药与临床杂志, 2022, 41(12): 759-765.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[19] |
孙李超越, 张子豪, 季文媛, 等. 药师基于疾病诊断相关分组规则保障用药合理性和经济性的探索[J]. 中国医院用药评价与分析, 2023, 23(5): 624-627.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[20] |
Introduction: The substantial financial burden associated with type 2 diabetes (T2D) over a lifetime cannot be neglected. Therefore, the objective of this study was to evaluate the pharmacoeconomic value of three once-weekly GLP-1 RAs, namely subcutaneous semaglutide (sc. SEMA), dulaglutide (DULA), and extended-release exenatide (e-r EXEN), in treating patients with T2D that cannot be controlled with metformin-based background therapy, and to find a suitable price reduction for non-cost-effective medications, to provide reasonable recommendations to the administration for adjusting drug prices.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[21] |
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[22] |
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[23] |
国务院办公厅. 国务院办公厅关于印发国家组织药品集中采购和使用试点方案的通知[EB/OL]. (2019-01-17) [2023-11-03]. http://www.nhc.gov.cn/bgt/gwywj2/201902/77f61ee4f5324788b2e0369681eae628.shtml.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
[24] |
屈茹楠, 高岸, 范国荣, 等. 国家带量采购政策对上海某院原研和仿制降压药使用状况的影响[J]. 中国药业, 2022, 31(15): 10-15.
{{custom_citation.content}}
{{custom_citation.annotation}}
|
{{custom_ref.label}} |
{{custom_citation.content}}
{{custom_citation.annotation}}
|
/
〈 |
|
〉 |