主办单位：上海医药行业协会
10 May 2025, Volume 46 Issue 5
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 3-8.
This consensus aims to address challenges in functional cosmetics R&D, including their unclear mechanisms, undefined targets, and inadequate evaluation systems, while promoting collaborative innovation across industry, academia, research, and medical sectors. The framework proposes a dermatological science-driven approach that integrates multi-omics research, artificial intelligence, and targeted delivery technologies to establish a comprehensive scientific system spanning skin phenotype analysis, active ingredient screening, and clinical validation. Its goal is to provide standardized guidance for the research and development of cosmetics, standardize the scientific basis for efficacy claims, help the high-quality development of the industry, and guide consumers to choose personalized service plans based on scientific evidence, so as to achieve accurate and professional skin health management.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 9-12.
This article reports a case of a 20-year-old female with Crohn’s disease complicated by a rare enterocutaneous fistula. She presented with a 4-year history of fatigue and 2-year history of intermittent abdominal pain and was initially misdiagnosed multiple times due to anemia and imaging studies suspected lymphoma. She was ultimately diagnosed with Crohn’s disease by multidisciplinary consultation combined with gastroscopy, colonoscopy, and small bowel CT examinations. During her disease course, complications occurred including gastrocolic fistula, coloabdominal wall fistula, abdominal wall abscess rupture and intestinal obstruction. She received treatment including anti-infection therapy, nutritional support, abscess drainage, and emergency surgery (terminal ileostomy)in succession and after postoperative continuous nutritional support and symptomatic management, her intestinal-dermal fistula healed, and the symptoms were significantly improved. This case suggests that early diagnosis of Crohn’s disease requires multidisciplinary collaboration and imaging assessment. Conservative management should be prioritized for severe complications like enterocutaneous fistulas, and surgical intervention may be necessary to improve prognosis.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 13-18.
Pemphigus is a group of autoimmune diseases characterized by blistering and erosions of the skin and mucous membranes, which can be life-threatening in severe cases. Currently, there is no effective cure for pemphigus. In addition to the incomplete understanding of the pathogenesis, the rarity of the disease and the lack of objective, standardized, and fully validated methods for evaluating the severity of pemphigus have affected the development of high-quality clinical research to some extent. In clinical trials, standardized evaluation methods are crucial for assessing disease severity and treatment efficacy. This article starts with the methods of evaluating the condition of pemphigus, systematically introducing the pemphigus disease area index, the autoimmune bullous skin disorder intensity score, the pemphigus vulgaris activity score, the pemphigus area and activity score, and the Japanese pemphigus disease severity score and other methods and scales for evaluating the condition of pemphigus. The strengths and limitations of each scoring system are discussed to provide reference for disease evaluation and efficacy assessment in clinical studies involving pemphigus patients.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 19-22.
Objective: To evaluate the clinical efficacy of Huang’s Xiangsheng pill combined with budesonide suspension in the treatment of chronic pharyngitis. Methods: Eighty-two patients with chronic pharyngitis were randomly divided into a control group and an observation group with forty-one cases each. Both groups received nebulized budesonide suspension, while the observation group was additionally treated with Huang’s Xiangsheng pill for 3 weeks. Clinical symptom scores (throat dryness and itching, foreign body sensation, burning sensation, sore throat, and cough), symptom relief time, routine blood tests (neutrophils and eosinophils), the levels of T lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺), treatment efficacy, and adverse events were compared between the two groups. Results: After treatment, the scores of dry throat itching, foreign body sensation, burning sensation, throat, cough, and the levels of neutrophil and eosinophil and CD8+ indicator were lower; the total effective rate, the levels of the indicators of CD3+, CD4+, and CD4+/CD8+ were higher; and the time for the disappearance of mucosal congestion, pharyngeal pain, dry throat itching, and hoarseness were shorter in the observation group than the control group (P<0.05). There was no statistically significant difference in adverse reactions between the two groups (P>0.05). Conclusion: The combination of Huang’s Xiangsheng pill with nebulized budesonide therapy can effectively reduce the level of inflammation indicators, quickly alleviate clinical symptoms, and regulate the immune function of patients and its medication in patients with chronic pharyngitis are safe and reliable.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 23-26.
As a traditional Chinese medicinal preparation, Wangshi Baochi pill has demonstrated significant efficacy in clinical treatments of digestive and respiratory system diseases in recent years. This article systematically reviews the progress of its application in infant, child and adult constipation, functional dyspepsia, diarrhea, anorexia, as well as pediatric pneumonia and cough, and discusses its mechanism of action. Wangshi Baochi pill exerts therapeutic effects through multiple components and targets, with a high safety profile. Innovative applications like acupoint application and its potential regulation of the brain-gut axis provide new directions for its future research.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 27-29.
Synopsis of Prescriptions of Golden Chamber is the section on miscellaneous diseases from the Treatise on Cold Damage and Miscellaneous Diseases, written by Zhang Zhongjing in the late Eastern Han Dynasty. It is a classical monograph of traditional Chinese medicine for the diagnosis and treatment of complex and chronic disorders, and pioneered the theoretical system of syndrome differentiation and treatment and its thinking method has universal guiding significance for clinical practice. Some common diseases and miscellaneous diseases in anorectal medicine and surgery could also be glimpsed in this book. This article mainly analyzes syndrome differentiation and treatment methods from some direct and indirect descriptions of hematochezia, anal sinusitis, perianal abscess, constipation, and ulcerative colitis in this book, so as to initially understand the inspiration and flexibility of Zhang Zhongjing’s treatment of miscellaneous diseases, and open up ideas for the clinical diagnosis and treatment of anorectal department.
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Exploring the treatment of hypothyroidism from the perspective of the “Circulation of One Qi” theoryShanghai Medical & Pharmaceutical Journal. 2025, 46(5): 30-32.
“Si Sheng Xin Yuan”, authored by Huang Yuanyu, a renowned physician of the Qing Dynasty, offers a profound exposition of human physiology and pathology through the concept of “One Qi,” and was the first to propose the innovative theory of the “Circulation of One Qi”. Inspired by this theory, this study investigates the pathogenesis and treatment of hypothyroidism from the perspective of Zhong Tu (central earth). It posits that the fundamental mechanism of the disease lies in the decline of Zhong Tu, resulting in impaired leftward ascent of Ji-earth, failure of clear Yang to rise, aggravation of cold-dampness, and weakened rightward descent of Wu-earth—ultimately leading to the collapse of Yang Qi and imbalance of Yin and Yang. As the spleen and stomach are regarded as the “foundation of postnatal life” and the “source of Qi and blood generation”, clinical application of the “Circulation of One Qi” theory prioritizes strengthening middle Qi. Impaired Zhong Tu leads to insufficient generation of Qi and blood and dysfunction of the viscera, manifesting as liver Qi stagnation, kidney Yang deficiency, and other patterns. Dampness obstructing the spleen further disrupts Qi dynamics, producing pathological substances such as blood stasis, phlegm turbidity, and fluid retention. Syndrome differentiation suggests that the liver, spleen, and kidney are primarily involved in hypothyroidism, with the spleen at the core. Thus, treatment should focus on reinforcing Zhong Tu, soothing the liver, and supporting both the spleen and kidney, offering a novel clinical approach for the prevention and treatment of hypothyroidism.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 33-35.
Objective: To investigate the efficacy of meshed xenogeneic acellular dermal matrix dressing combined with activated carbon dressing in the treatment of deep second-degree burn wounds. Methods: Eighty-two pediatric patients with deep second-degree burns were randomly divided into a control group (n=41) and an observation group (n=41). The control group received conventional wound debridement, while the observation group was treated with xenogeneic acellular dermal matrix dressing combined with activated carbon dressing. Serum inflammatory cytokine levels, wound healing outcomes, and adverse reactions were compared between the two groups. Results: At 24 hours post-treatment, the observation group showed lower serum TNF-α and IL-6 levels, higher IL-10 levels, fewer dressing changes, shorter wound healing time and total hospital stay, lower rates of scar hyperplasia, and fewer adverse reactions compared to the control group (all P<0.05). Conclusion: The combination therapy can effectively improve serum inflammatory cytokine levels, accelerate wound healing, and reduce complications in pediatric patients with deep second-degree burns.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 36-40.
Objective: To explore the safety and effectiveness of scalp nerve block (SNB) in frontal placeholder surgery. Methods: A total of 86 patients who underwent frontal placeholder surgery were selected and randomly divided into a SNB group (group B) and a control group (group C) with 43 cases each. Group B underwent ultrasound-guided SNB before general anesthesia and group C underwent general anesthesia. Their hemodynamic indexes were collected before surgery (T0), at head nailing (T1), at skin cutting (T2), at cranial sawing (T3) and at the end of the operation (T4). The levels of blood plasma cortisol, blood glucose and C-reactive protein were determined before and after anesthesia. The VAS score, the incidence of post-extubation agitation and nausea and vomiting, the rate of postoperative use of analgesics and hospital stay were compared between the two groups after awakening. Results: Mean arterial pressure (MAP) and heart rate (HR) at T1-T4 in group C were significantly higher than those at T0 (P<0.001) and significantly lower in group B than group C. MAP in group B at T3 and T4 was significantly lower than that at T0 (P<0.05). The levels of postoperative blood glucose, C-reactive protein and plasma cortisol in both groups were significantly higher than those before anesthesia and group B were significantly lower than group C (P<0.05). The dosage of sufentanil and VAS scores in group B were lower than those in group C (P<0.001). The incidence of post-extubation agitation and nausea and vomiting and the rate of postoperative use of analgesics were lower in the group B than group C (P<0.05). Conclusion: Ultrasound-guided SNB can maintain hemodynamic stability in patients undergoing frontal placeholder surgeries and reduce stress response, inflammatory factor levels, pain intensity and analgesic drug use and incidence of adverse event.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 41-44.
Objective: To investigate the clinical efficacy of shoulder arthroscopic single-row and double-row suture bridge repair techniques in elderly patients with rotator cuff tears. Methods: The medical data from 60 elderly patients with rotator cuff tears were retrospectively analyzed and they were divided into a single-row group (n=30) and a double-row group (n=30) based on surgical technique. The single-row group underwent single-row suture bridge repair, while the double-row group received double-row suture bridge repair. Shoulder range of motion (forward flexion, abduction, external rotation), pain severity (visual analog scale, VAS), shoulder function scores (UCLA, ASES, CM), activities of daily living (modified Barthel index, MBI), overall effectiveness rate and re-tear rate were compared between the two groups. Results: The double-row group demonstrated significantly better outcomes in shoulder range of motion (forward flexion, abduction, external rotation), UCLA score, ASES score, CM score, and MBI score compared to the single-row group. Additionally, the double-row group exhibited lower VAS scores, reduced re-tear rates and a higher overall effectiveness rate. Conclusion: Arthroscopic double-row suture bridge repair is more effective in improving shoulder function, alleviating pain and reducing re-tear risk in elderly patients with rotator cuff tears, yielding superior clinical outcomes compared to single-row repair.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 45-48.
Objective: To investigate the effects of lower limb rehabilitation robots combined with neuromuscular activation techniques integrated with suspension exercise training on the rehabilitation of lower limb function in patients with hemiplegia after cerebral infarction. Methods: Sixty-four patients with hemiplegia after cerebral infarction were randomly divided into a control group (n=32) and an observation group (n=32). The control group received routine rehabilitation interventions, while the observation group was given neuromuscular activation techniques combined with lower limb rehabilitation robots and suspension exercise training. muscle strength level, lower limb motor function (Fugl-Meyer assessment for lower extremity, FMA-LE), balance function (Berg balance scale, BBS), walking ability (10 m MWS, stride length, step width) and quality of life (stroke-specific quality of life scale, SS-QOL) were compared between the two groups. Results: After training, the observation group demonstrated significantly higher muscle strength level, FMA-LE scores, BBS scores, SS-QOL scores, 10 m MWS, stride length and step width compared to the control group (all P<0.05). Conclusion: The combination therapy can enhance muscle strength level, improve lower limb motor function, balance, walking ability, and further elevate the quality of life in patients with hemiplegia after cerebral infarction.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 49-51.
Objective: To analyze the efficacy of transcranial color Doppler ultrasound (TCD) in the diagnosis of internal carotid artery stenosis in patients with transient ischemic attack (TIA). Methods: Ninety-eight TIA patients admitted to our hospital were allocated into an observation group, and 75 healthy individuals who underwent physical examinations in our hospital were selected as a control group. TCD examination was performed on all subjects, and the differences in TCD blood flow parameters between the positive and negative sides of the observation group and the control group were statistically analyzed. The diagnostic efficacy of TCD blood flow parameters in carotid artery stenosis in TIA patients was analyzed. Results: The end diastolic blood flow velocity (EDV), maximum systolic flow velocity (PSV), pulsatility index (PI), and resistance index (RI) of the positive side of the observation group were higher than those of the negative side and the control group, and all blood flow parameters of the negative side of the observation group were higher than those of the control group (P<0.05); The ROC curve showed that the area under the curve (AUC) of the combination determination of EDV, PSV, PI and RI was higher than that of each individual determination. Conclusion: TCD can diagnose internal carotid artery stenosis in TIA patients to a certain extent and has high diagnostic efficacy, which is worthy of clinical further trials.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 52-56.
Non-tuberculous mycobacteria (NTM) are common pathogens causing opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS), with Mycobacterium avium being the most frequently isolated species. In recent years, the incidence of NTM infections among patients with AIDS has been increasing worldwide. Due to overlapping clinical manifestations, NTM infections are often misdiagnosed as Mycobacterium tuberculosis, leading to inappropriate treatment. This article reviews recent advances in the research of human immunodeficiency virus (HIV) co-infection with NTM, aiming to enhance clinicians’ understanding of this opportunistic pathogen.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 57-60.
Objective: To investigate and analyze the use of antidepressants in a mental health center so as promote the rational and safe use of these drugs in clinical practice. Methods: The data of eighteen antidepressants used in the mental health center in 2018-2022 were collected, and their consumption amount and frequency were statistically analyzed. Results: The frequency of use and consumption amount of the top ten antidepressants were basically the same, especially with venlafaxine (consumption amount of 18.111 2 million yuan, percentage of consumption amount 18.48%, usage frequency of 18.99%), paroxetine (consumption amount of 7.371 1 million yuan, percentage of consumption amount 7.52%, usage frequency of 18.59%), and citalopram (consumption amount of 23.150 5 million yuan, percentage of consumption amount 23.62%, usage frequency of 14.22%) accounting for the largest proportion. The consumption of most antidepressants was positively correlated with the frequency of their use. Conclusion: The selection of antidepressant drug varieties in this mental health center basically meets the requirements of the guidelines, but there are still some shortcomings.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 61-65.
Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system disease with demyelination injury as the main manifestation, which has a high disability rate due to untimely diagnosis and treatment. This article reports a case of NMOSD patient presenting with onset of weakness in both lower extremities and progressive aggravation, and his curative effect is obvious after treatments with the combination of traditional Chinese medicine decoction, acupuncture and conventional Western medicine, and he can walk slowly. Additionally, the literature related to NMOSD is also reviewed.
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Application and practice of data connection mode based on eSource to EDC system in clinical researchShanghai Medical & Pharmaceutical Journal. 2025, 46(5): 66-70.
Objective: To explore and evaluate the feasibility of electronic source data (eSource) docking electronic data capture (EDC) system integration in investigator-initiated trials (IIT). Methods: Based on the existing data platform of hospitals, a solution was designed and implemented to enable automatic data collection by direct connection between eSource and EDC. An ongoing IIT was selected to test and compare the effectiveness between the eSource docking EDC data collection mode and traditional manual data entry mode. Results: Compared to the traditional mode, the eSource docking EDC mode could reduce the average time for data collection by approximately 90% per case and decreased the average number of data modifications by around 78% per case. Conclusion: The implementation of eSource docking EDC data collection mode may be of benefit to enhancing the level of informatization in clinical research, and can improve the efficiency and accuracy of data collection and reduce the workload for researchers, demonstrating significant potential for practical applications.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 71-73.
Based on the business practices of Shanghai Pharmaceuticals Holding Co., Ltd., this study conducts a systematic analysis of the construction logic and operational mechanisms of the enterprise’s strategic performance management system. Focusing on examining the ensuring role of performance management tools in strategy implementation processes, it elucidates implementation pathways for synergistic development between strategic objectives and performance systems. The research provides practical insights for large-scale conglomerates to achieve organic integration of strategy and performance.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 74-78.
Objective: To establish a scientific and rational evaluation system for hospital pharmacy personnel, clarify multi-level indicators and their weights, and provide a basis for performance appraisal of pharmacists in different positions. Methods: The Delphi method was used to screen evaluation indicators, and the direct scoring method was adopted to determine weight coefficients. An evaluation index system was developed for three kind of pharmacist roles (research pharmacists, dispensing pharmacists, and clinical pharmacists) in our hospital. Results: The final system consisted of 5 primary indicators and 22 secondary indicators. The evaluation of research pharmacists emphasized on professional knowledge and research ability; dispensing pharmacists focus on professional knowledge and basic skills and clinical pharmacists are assessed mainly on professional knowledge and moral integrity. Expert-assigned weights for all three roles showed good consistency (CR values: 0.053 6, 0.060 2, and 0.049 8, respectively). The overall coordination index among experts was Ca=0.81, and Kendall’s W ranged from 0.6 to 0.7. Conclusion: After two rounds of expert consultation, the indicator system proves to be stable and feasible. After two rounds of expert consultation, the index system is stable and feasible, which can fully reflect the comprehensive quality of hospital pharmacists and has good application and promotion value.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 79-83.
Clinical pharmacists provided pharmaceutical care for a patient with advanced lung squamous cell carcinoma undergoing treatment with paclitaxel (albumin bound) combined with carboplatin. A correlation analysis of their severe gastrointestinal reactions and myelosuppression observed was carried out and the polymorphisms of MTHFR, ABCB1, GSTP1, CYP3A4, and CYP3A5 genes were detected. Based on the genetic test results, the clinical pharmacists identified factors associated with severe adverse reactions and proposed medication recommendations. Clinical pharmacists can offer pharmaceutical technical support to ensure safe and effective medication use for patients.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 84-87.
The process for the removal residual host cell DNA (HCD) in the production of oncolytic adenovirus was optimized and meanwhile, the differences in the removal HCD effect of domestic and imported commercial nucleases were compared. In addition, the operable area of nuclease concentration and digestion time for controlling HCD content in the production of oncolytic adenovirus was fitted by the design of experiment.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 88-91.
Objective: An ion chromatography (IC) method was established for the quantitative determination of nitrite in ornidazole injection. Methods: IC was run on Thermo Dionex IonPac AS9-HC and the RFIC anion chromatographic column (4 mm×250 mm） using a conductivity detector and potassium hydroxide solution (6 mmol/L) as eluent at flow rate 1.0 mL/min and sample volume 20 μL. Results: The regression equation was y=0.210 7 x+0.104 5 with r2=0.997 8, the linear relationship of the standard curve was good when the nitrite concentrations were 1.64-32.73 μg/mL, the limit of quantification was 1.64 μg/mL, and the recoveries of low, medium and high concentrations of samples were 98.45%, 99.61% and 97.23%, respectively. Conclusion: The method can be used for the determination of nitrite in ornidazole injection by methodological validation, which can provide reference for quality control.
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Shanghai Medical & Pharmaceutical Journal. 2025, 46(5): 92-95.
Objective: To establish a method for the extraction of the elements of magnesium, aluminum, silicon and calcium of plastic ampoules in hypertonic solutions and the determination of their migration contents. Methods: The plastic ampoules were sterilized in 50% glucose or 10% sodium chloride hypertonic solution at 121 ℃ for 1 h, and the element magnesium, aluminum, silicon and calcium migrated were extracted. In addition, they were placed under accelerated test conditions for different time to investigate their migration, and their contents were determined by ICP-OES. Results: The element magnesium, aluminum, silicon and calcium showed excellent linearity, recovery and precision in their respective concentration range. Conclusion: The method is accurate, sensitive and easy to operate, which can provide data reference for the safety evaluation of plastic ampoules.
